Szpiech Lab

Population Genetics | Evolutionary Genomics

Population Genetics

We use theory, simulations, and large scale data analysis to address questions pertaining to the relationship between recent demographic history, inbreeding, and natural selection on the distribution of genetic variation within and between populations.

Evolution of Populations

Populations adapt to their local environment in order to survive and thrive. In a rapidly changing world, it is critical to understand the ways in which populations are shaped in response to their environment. We develop methods and software aimed at identifying the genomic consequences of adaptation to local environments.

Complex Traits

We are interested in understanding how the distribution of complex traits within and between populations is affected by population history and evolutionary forces. Through simulations and data analysis, we aim to exploit our knowledge of these processes to learn about the origin and genetic architecture of disease and other phenotypes.